RFC5

Across TCGA patient cohorts, RFC5 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFC5-associated genes across cancer lineages are A-Raf_pS299, FoxM1, and ACC_pS79. Each is linked with RFC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFC5-to-partner and partner-to-RFC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by RFC5-low versus RFC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFC5→partner) and Y-score (partner→RFC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.152	-2.222	.002	.011	3	1
UCEC	FoxM1 →	+0.251	+2.222	.022	.011	3	1
UCEC	ACC_pS79 →	+0.303	+2.469	.039	.010	3	1
UCEC	G6PD →	-0.317	-3.439	.021	.005	3	1
UCEC	ACC1 →	+0.326	+2.222	.034	.011	3	1
UCEC	INPP4B →	-0.307	-3.169	.025	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

A-Raf_pS299 by RFC5 expression — UCEC

Explore this box plot interactively →