RFC5

Across TCGA cell cohorts, RFC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,231 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RFC5-associated GO terms across cancer lineages are Centrosome cycle, Centriole replication, and DNA recombination. Each is linked with RFC5 in more than 19 cancer types. Because this analysis shows association rather than direction, both RFC5-to-partner and partner-to-RFC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome cycle grouped by RFC5-low versus RFC5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFC5→partner) and Y-score (partner→RFC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.100	+1.476	<.001	<.001	3	20
BONE	Centriole replication →	+0.152	+1.221	<.001	.003	3	20
OESOPHAGUS	DNA recombination →	+0.079	+0.854	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation involved in DNA replication →	+0.204	+1.842	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Regulation of cell cycle checkpoint →	+0.140	+1.512	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.214	+1.850	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,231 associations by consensus.

Centrosome cycle by RFC5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →