RFC5

Across TCGA cell cohorts, RFC5 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RFC5-associated genes across cancer lineages are C1QA and CCL18. Each is linked with RFC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFC5-to-partner and partner-to-RFC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QA grouped by RFC5-low versus RFC5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFC5→partner) and Y-score (partner→RFC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QA →	+0.204	+4.095	<.001	.009	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

C1QA by RFC5 expression — LARGE_INTESTINE

Explore this box plot interactively →