RFC3

Across TCGA pan-cancer cohorts, RFC3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RFC3 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RFC3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RFC3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where RFC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.380	1.000	.008	45	view →
PDAC	OS	Quartile	All	0.338	0.685	<.001	23	view →
CCRCC	OS	Quartile	II,III,IV	0.249	0.959	.019	14	view →
LUAD	DFS	Quartile	III,IV	0.995	0.415	.019	13	view →
LSCC	DFS	Median	II,III,IV	0.849	0.558	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RFC3–HNSC (OS)

Open the HNSC breakdown →