RFC1

Across TCGA pan-cancer cohorts, RFC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RFC1 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RFC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RFC1 expression acts as an unfavorable survival marker.

HNSC, PDAC, and UCEC are the cancer types where RFC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.745	0.911	.016	27	view →
PDAC	OS	Median	II,III,IV	0.418	0.629	<.001	24	view →
UCEC	DFS	Median	All	0.853	0.954	.022	10	view →
CCRCC	OS	Quartile	II,III,IV	0.508	0.870	.021	5	view →
LSCC	DFS	Median	II,III,IV	0.498	0.919	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RFC1–HNSC (OS)

Open the HNSC breakdown →