RFC1

Across TCGA patient cohorts, RFC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,763 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RFC1-associated proteins across cancer lineages are RFC1_T506, PDS5A, and UBE2K. Each is linked with RFC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both RFC1-to-partner and partner-to-RFC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RFC1 versus RFC1_T506 in UCEC, with a Pearson correlation of 0.24.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RFC1→partner) and Y-score (partner→RFC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RFC1_T506 →	+0.849	+0.503	<.001	.004	3	7
LSCC	PDS5A →	+0.309	+0.492	<.001	<.001	3	6
LUAD	UBE2K →	+0.207	+0.283	<.001	.002	3	5
GBM	NSD2 →	+0.620	+0.389	<.001	<.001	3	5
UCEC	RFC1_S368 →	+0.689	+0.553	<.001	.001	2	6
GBM	RFC2 →	+0.343	+0.228	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,763 associations by consensus.

RFC1 vs RFC1_T506 — UCEC

Explore this scatter interactively →