RFC1

Across TCGA cell cohorts, RFC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,875 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RFC1-associated GO terms across cancer lineages are Positive regulation of chromosome condensation, Regulation of chromosome condensation, and Protein branched polyubiquitination. Each is linked with RFC1 in more than 17 cancer types. Because this analysis shows association rather than direction, both RFC1-to-partner and partner-to-RFC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromosome condensation grouped by RFC1-low versus RFC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFC1→partner) and Y-score (partner→RFC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of chromosome condensation →	+0.235	+0.808	.002	<.001	3	18
SOFT_TISSUE	Regulation of chromosome condensation →	+0.213	+0.911	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Protein branched polyubiquitination →	+0.130	+1.200	<.001	<.001	3	15
SOFT_TISSUE	Mitotic chromosome condensation →	+0.168	+0.898	<.001	<.001	3	14
BREAST	Negative regulation of cell cycle process →	+0.078	+1.150	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Regulation of sister chromatid segregation →	+0.132	+0.907	<.001	.007	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,875 associations by consensus.

Positive regulation of chromosome condensation by RFC1 expression — BONE

Explore this box plot interactively →