RFC1

Across TCGA cell cohorts, RFC1 mutation is significantly associated with the RNA expression of many other genes, with 126 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RFC1-associated genes across cancer lineages are DPRX, PRM2, and PRR30. Each is linked with RFC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFC1-to-partner and partner-to-RFC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by RFC1-low versus RFC1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFC1→partner) and Y-score (partner→RFC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DPRX →	+0.052	+5.369	<.001	.004	3	2
BLOOD_Leukemia	PRM2 →	+0.042	+4.969	<.001	.003	3	2
CNS	PRR30 →	+0.018	+3.643	<.001	.007	3	2
SOFT_TISSUE	IFNA14 →	+0.032	+5.369	<.001	.004	3	1
KIDNEY	CNBD1 →	+0.148	+3.584	.001	.008	3	1
OVARY	KRTAP11-1 →	+0.083	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 126 associations by consensus.

DPRX by RFC1 expression — SOFT_TISSUE

Explore this box plot interactively →