REXO5

Across TCGA patient cohorts, REXO5 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REXO5-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and A-Raf_pS299. Each is linked with REXO5 in more than 1 cancer types. Because this analysis shows association rather than direction, both REXO5-to-partner and partner-to-REXO5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by REXO5-low versus REXO5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REXO5→partner) and Y-score (partner→REXO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.079	-3.558	.021	.002	3	1
UCEC	eIF4E →	+0.176	+1.807	.014	.004	3	1
UCEC	A-Raf_pS299 →	-0.106	-2.000	.009	.029	3	1
UCEC	JNK2 →	+0.172	+1.247	.011	.045	3	1
UCEC	MEK1 →	+0.417	+3.807	<.001	<.001	3	1
UCEC	Mre11 →	-0.062	-3.143	.033	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

14-3-3_beta by REXO5 expression — UCEC

Explore this box plot interactively →