REXO4

Across TCGA pan-cancer cohorts, REXO4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated REXO4 data layer compared with 30 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher REXO4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated REXO4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BLCA, UCEC, and CESC are the cancer types where REXO4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.082	0.582	<.001	12	view →
UCEC	DFS	Median	II,III,IV	1.000	0.443	.029	12	view →
CESC	OS	Median	All	0.576	0.875	.041	6	view →
HNSC	OS	Median	All	0.187	0.685	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

REXO4–BLCA (OS)

Open the BLCA breakdown →