REXO4

Across TCGA patient cohorts, REXO4 protein abundance is significantly associated with the RNA expression of many other genes, with 20,909 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible REXO4-associated genes across cancer lineages are ALG3, TPX2, and CENPA. Each is linked with REXO4 in more than 8 cancer types. Because this analysis shows association rather than direction, both REXO4-to-partner and partner-to-REXO4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, REXO4 versus ALG3 in LSCC, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REXO4→partner) and Y-score (partner→REXO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ALG3 →	+0.828	+0.490	<.001	<.001	3	9
LUAD	TPX2 →	+1.135	+0.387	<.001	<.001	3	8
OV	CENPA →	+1.267	+0.270	<.001	.002	3	7
BRCA	CDCA8 →	+1.096	+0.484	<.001	<.001	3	7
BRCA	KIF2C →	+1.341	+0.508	<.001	<.001	3	7
UCEC	CDCA5 →	+1.153	+0.320	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,909 associations by consensus.

REXO4 vs ALG3 — LSCC

Explore this scatter interactively →