REXO2

Across TCGA patient cohorts, REXO2 mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible REXO2-associated genes across cancer lineages are MTATP6P31, MRPS16P2, and MTND5P40. Each is linked with REXO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both REXO2-to-partner and partner-to-REXO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTATP6P31 grouped by REXO2-low versus REXO2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REXO2→partner) and Y-score (partner→REXO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MTATP6P31 →	+0.051	+4.685	<.001	.007	3	2
BLCA	MRPS16P2 →	+0.083	+4.588	<.001	.008	3	2
BLCA	MTND5P40 →	+0.139	+6.040	<.001	.001	3	2
BLCA	LINC02563 →	+0.793	+4.788	<.001	.006	3	2
BLCA	SSX4 →	+0.029	+4.788	.004	.006	3	2
UCEC	CENPX →	+0.813	+3.201	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

MTATP6P31 by REXO2 expression — BLCA

Explore this box plot interactively →