REXO1

Across TCGA patient cohorts, REXO1 mutation is significantly associated with the RNA expression of many other genes, with 3,304 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REXO1-associated genes across cancer lineages are AP1S3, EME1, and SFXN1. Each is linked with REXO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both REXO1-to-partner and partner-to-REXO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP1S3 grouped by REXO1-low versus REXO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REXO1→partner) and Y-score (partner→REXO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AP1S3 →	+0.636	+2.807	<.001	<.001	3	3
UCEC	EME1 →	+0.573	+2.069	<.001	<.001	3	3
COAD	SFXN1 →	+0.546	+3.342	.001	.005	3	3
UCEC	CENPN →	+0.774	+2.399	<.001	<.001	3	3
UCEC	CRK →	+0.433	+3.939	<.001	<.001	3	3
UCEC	PDP2 →	+0.370	+1.841	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,304 associations by consensus.

AP1S3 by REXO1 expression — UCEC

Explore this box plot interactively →