REXO1

Across TCGA patient cohorts, REXO1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REXO1-associated genes across cancer lineages are TSC1, Bcl-2, and eEF2. Each is linked with REXO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both REXO1-to-partner and partner-to-REXO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSC1 grouped by REXO1-low versus REXO1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REXO1→partner) and Y-score (partner→REXO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TSC1 →	-0.536	-3.000	<.001	.035	3	3
BLCA	Bcl-2 →	-0.222	-3.000	.024	.036	3	2
UCEC	eEF2 →	+0.326	+2.584	.008	.010	3	2
UCEC	EGFR_pY1068 →	-0.236	-1.440	.006	.024	3	2
UCEC	eIF4E →	+0.243	+3.713	<.001	<.001	3	2
UCEC	Notch1 →	+0.134	+1.440	.006	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

TSC1 by REXO1 expression — COAD

Explore this box plot interactively →