REXO1

Across TCGA cell cohorts, REXO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,933 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible REXO1-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Cytoplasm protein quality control by the ubiquitin-proteasome system, and Cytoplasm protein quality control. Each is linked with REXO1 in more than 16 cancer types. Because this analysis shows association rather than direction, both REXO1-to-partner and partner-to-REXO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by REXO1-low versus REXO1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (REXO1→partner) and Y-score (partner→REXO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.192	+1.042	<.001	<.001	3	17
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.170	+0.842	<.001	<.001	3	17
BONE	Cytoplasm protein quality control →	+0.147	+0.924	<.001	<.001	3	16
BONE	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.098	+0.952	.002	.001	3	16
BONE	Electron transport coupled proton transport →	+0.098	+0.952	.002	.001	3	16
BLOOD_Leukemia	Negative regulation of DNA-templated transcription initiation →	+0.113	+0.644	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,933 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by REXO1 expression — BONE

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