REXO1

Across TCGA cell cohorts, REXO1 mutation is significantly associated with the RNA expression of many other genes, with 552 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible REXO1-associated genes across cancer lineages are ICOS, ELOA3DP, and PRR23C. Each is linked with REXO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both REXO1-to-partner and partner-to-REXO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ICOS grouped by REXO1-low versus REXO1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REXO1→partner) and Y-score (partner→REXO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ICOS →	+0.122	+4.058	.001	.001	3	2
SOFT_TISSUE	ELOA3DP →	+0.159	+3.597	.001	.006	3	2
OVARY	PRR23C →	+0.006	+4.990	.003	.001	3	2
BLOOD_Leukemia	GPR63 →	+1.103	+3.115	<.001	.009	3	2
LARGE_INTESTINE	NPRL2 →	+0.453	+2.043	.001	.008	3	2
BLOOD_Leukemia	TTI2 →	+0.451	+3.351	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 552 associations by consensus.

ICOS by REXO1 expression — SOFT_TISSUE

Explore this box plot interactively →