REV3L

Across TCGA patient cohorts, REV3L mutation is significantly associated with the RNA expression of many other genes, with 7,040 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REV3L-associated genes across cancer lineages are PSMB1, MRPL18, and GSR. Each is linked with REV3L in more than 4 cancer types. Because this analysis shows association rather than direction, both REV3L-to-partner and partner-to-REV3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMB1 grouped by REV3L-low versus REV3L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REV3L→partner) and Y-score (partner→REV3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMB1 →	+0.175	+1.277	.008	.002	3	5
UCEC	MRPL18 →	+0.266	+1.312	<.001	<.001	3	5
LUAD	GSR →	+0.836	+3.530	.004	.002	3	4
UCEC	ALPL →	-0.715	-1.000	.002	.003	3	4
UCEC	H2AZ1 →	+0.611	+1.958	<.001	<.001	3	4
STAD	UTP15 →	+0.481	+3.264	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,040 associations by consensus.

PSMB1 by REV3L expression — UCEC

Explore this box plot interactively →