REV3L

Across TCGA patient cohorts, REV3L mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REV3L-associated genes across cancer lineages are 4E-BP1, ATM, and TFRC. Each is linked with REV3L in more than 3 cancer types. Because this analysis shows association rather than direction, both REV3L-to-partner and partner-to-REV3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by REV3L-low versus REV3L-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REV3L→partner) and Y-score (partner→REV3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.426	+3.999	<.001	<.001	3	4
COAD	ATM →	-0.568	-2.700	<.001	.005	3	4
UCEC	TFRC →	+0.471	+1.338	<.001	<.001	3	4
COAD	Rictor →	-0.943	-3.169	.011	.017	3	3
STAD	FoxM1 →	+0.280	+1.700	.005	.042	3	3
LUAD	Cyclin-B1 →	+0.694	+3.000	.009	.036	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

4E-BP1 by REV3L expression — STAD

Explore this box plot interactively →