REV3L

Across TCGA cell cohorts, REV3L mutation is significantly associated with the RNA expression of many other genes, with 577 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible REV3L-associated genes across cancer lineages are OR2B3, C18orf63, and OR2T2. Each is linked with REV3L in more than 2 cancer types. Because this analysis shows association rather than direction, both REV3L-to-partner and partner-to-REV3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2B3 grouped by REV3L-low versus REV3L-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REV3L→partner) and Y-score (partner→REV3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR2B3 →	+0.061	+4.736	<.001	.009	3	3
BLOOD_Lymphoma	C18orf63 →	+0.008	+3.130	<.001	.006	3	2
CNS	OR2T2 →	+0.011	+4.357	<.001	.004	3	2
SKIN	UBQLN3 →	+0.006	+3.415	<.001	.001	3	2
SKIN	AMY2A →	+0.050	+3.023	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	KCNK18 →	+0.059	+4.736	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 577 associations by consensus.

OR2B3 by REV3L expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →