RETREG2

Across TCGA patient cohorts, RETREG2 mutation is significantly associated with the RNA expression of many other genes, with 1,490 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RETREG2-associated genes across cancer lineages are CARD18, MIR3651, and XIRP1. Each is linked with RETREG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RETREG2-to-partner and partner-to-RETREG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CARD18 grouped by RETREG2-low versus RETREG2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RETREG2→partner) and Y-score (partner→RETREG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CARD18 →	+1.097	+3.767	.001	.003	3	2
BLCA	MIR3651 →	+0.430	+3.173	.006	.006	3	2
UCEC	XIRP1 →	+0.209	+2.057	<.001	.008	3	2
SKCM	RNU7-10P →	+0.568	+3.717	<.001	.001	3	2
LUSC	RPSAP32 →	+0.094	+3.578	<.001	.002	3	2
LUSC	RPL22P5 →	+0.098	+4.200	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,490 associations by consensus.

CARD18 by RETREG2 expression — BLCA

Explore this box plot interactively →