RETREG1

Across TCGA patient cohorts, RETREG1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RETREG1-associated genes across cancer lineages are FoxM1, Paxillin, and IRS1. Each is linked with RETREG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RETREG1-to-partner and partner-to-RETREG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RETREG1-low versus RETREG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RETREG1→partner) and Y-score (partner→RETREG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.224	+2.115	.048	.019	3	2
UCEC	Paxillin →	+0.226	+2.331	.046	.019	3	2
UCEC	IRS1 →	+0.234	+2.115	.009	.019	3	1
UCEC	MEK1 →	+0.449	+3.169	.004	.018	3	1
UCEC	Notch1 →	+0.213	+2.807	<.001	.003	3	1
UCEC	p27_pT198 →	+0.098	+3.000	.036	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FoxM1 by RETREG1 expression — UCEC

Explore this box plot interactively →