RETNLB

Across TCGA patient cohorts, RETNLB mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RETNLB-associated genes across cancer lineages are Caspase-7-cleavedD198, Rb_pS807_S811, and TFRC. Each is linked with RETNLB in more than 2 cancer types. Because this analysis shows association rather than direction, both RETNLB-to-partner and partner-to-RETNLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RETNLB-low versus RETNLB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RETNLB→partner) and Y-score (partner→RETNLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.664	+2.827	.041	.035	3	3
SKCM	Rb_pS807_S811 →	+0.510	+2.321	.018	.035	3	2
SKCM	TFRC →	+0.683	+2.321	.013	.035	2	2
UCEC	A-Raf_pS299 →	-0.272	-3.000	<.001	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.216	-3.169	.019	.019	3	1
UCEC	MEK1 →	+0.578	+3.169	.003	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Caspase-7-cleavedD198 by RETNLB expression — UCEC

Explore this box plot interactively →