RESF1

Across TCGA patient cohorts, RESF1 mutation is significantly associated with the total protein of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RESF1-associated genes across cancer lineages are PKC-a_pS657, JNK_pT183_Y185, and PDCD4. Each is linked with RESF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RESF1-to-partner and partner-to-RESF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a_pS657 grouped by RESF1-low versus RESF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RESF1→partner) and Y-score (partner→RESF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-a_pS657 →	-0.287	-2.321	.015	.033	3	4
UCEC	JNK_pT183_Y185 →	-0.139	-1.584	.003	.008	3	3
COAD	PDCD4 →	-0.468	-2.459	.003	.018	3	3
UCEC	RBM15 →	+0.182	+1.713	.044	.024	3	3
COAD	ATM →	-0.661	-2.898	<.001	.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.030	+2.230	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

PKC-a_pS657 by RESF1 expression — COAD

Explore this box plot interactively →