RERG

Across TCGA pan-cancer cohorts, RERG mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RERG data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RERG mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RERG expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where RERG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.990	0.685	<.001	47	view →
CCRCC	DFS	Median	III,IV	0.821	0.536	.019	8	view →
LUAD	OS	Median	III,IV	0.779	0.323	.024	8	view →
OV	DFS	Median	All	0.841	1.000	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RERG–PDAC (OS)

Open the PDAC breakdown →