RERG

Across TCGA patient cohorts, RERG mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RERG-associated genes across cancer lineages are PCNA, EGFR, and INPP4B. Each is linked with RERG in more than 1 cancer types. Because this analysis shows association rather than direction, both RERG-to-partner and partner-to-RERG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by RERG-low versus RERG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RERG→partner) and Y-score (partner→RERG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.288	+2.906	.001	.001	3	2
UCEC	EGFR →	-0.197	-3.143	.003	.018	3	1
UCEC	INPP4B →	-0.315	-3.169	.022	.018	3	1
UCEC	Ku80 →	+0.326	+2.235	.001	.006	3	1
UCEC	p27_pT198 →	+0.116	+2.321	.010	.034	3	1
UCEC	PDCD4 →	-0.698	-2.222	<.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PCNA by RERG expression — UCEC

Explore this box plot interactively →