RERE

Across TCGA pan-cancer cohorts, RERE mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RERE’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RERE mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RERE is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

LUAD, LSCC, and PDAC are the cancer types where RERE tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RERE mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.186	<.001	8	view →
LSCC	All	All	+0.082	.010	3	view →
PDAC	Male	All	−0.207	.010	2	view →
CCRCC	Female	IV	−0.292	.021	1	view →
HNSC	All	IV	−0.190	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RERE–LUAD

Open the LUAD breakdown →