RERE

Across TCGA patient cohorts, RERE mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RERE-associated genes across cancer lineages are eEF2, MEK1, and c-Kit. Each is linked with RERE in more than 4 cancer types. Because this analysis shows association rather than direction, both RERE-to-partner and partner-to-RERE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RERE-low versus RERE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RERE→partner) and Y-score (partner→RERE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.291	+1.514	.005	.012	3	5
SKCM	MEK1 →	+0.277	+2.000	.046	.009	3	3
STAD	c-Kit →	-0.304	-3.321	.041	.010	3	3
UCEC	mTOR_pS2448 →	-0.108	-2.401	.013	.002	3	3
COAD	ATM →	-0.931	-3.000	<.001	.034	3	3
UCEC	Di-Ras3 →	-0.090	-1.241	.040	.015	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

eEF2 by RERE expression — UCEC

Explore this box plot interactively →