RERE

Across TCGA cell cohorts, RERE mutation is significantly associated with the RNA expression of many other genes, with 1,018 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RERE-associated genes across cancer lineages are ZC3H10, LYG1, and SAMD8. Each is linked with RERE in more than 2 cancer types. Because this analysis shows association rather than direction, both RERE-to-partner and partner-to-RERE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZC3H10 grouped by RERE-low versus RERE-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RERE→partner) and Y-score (partner→RERE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZC3H10 →	+0.357	+2.130	.001	<.001	3	3
LARGE_INTESTINE	LYG1 →	+0.695	+2.000	.002	.009	3	3
LARGE_INTESTINE	SAMD8 →	+0.481	+2.584	.002	.002	3	3
LARGE_INTESTINE	DBF4B →	+0.588	+3.169	.003	.006	3	3
LARGE_INTESTINE	DCP2 →	+0.536	+1.721	.003	.003	3	3
LARGE_INTESTINE	GTF2H4 →	+0.541	+2.130	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,018 associations by consensus.

ZC3H10 by RERE expression — LARGE_INTESTINE

Explore this box plot interactively →