RER1

Across TCGA pan-cancer cohorts, RER1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RER1 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RER1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RER1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where RER1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.277	0.488	.001	40	view →
HNSC	DFS	Tertile	All	0.831	0.584	.009	11	view →
CCRCC	DFS	Quartile	III,IV	0.229	0.726	.002	9	view →
LUAD	OS	Quartile	III,IV	1.000	0.326	.031	4	view →
GBM	DFS	Tertile	All	0.681	0.831	.022	3	view →
LSCC	OS	Quartile	All	0.769	0.960	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RER1–PDAC (DFS)

Open the PDAC breakdown →