REPS2

Across TCGA patient cohorts, REPS2 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REPS2-associated genes across cancer lineages are eIF4E, ACC1, and Shc_pY317. Each is linked with REPS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both REPS2-to-partner and partner-to-REPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by REPS2-low versus REPS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REPS2→partner) and Y-score (partner→REPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.167	+3.598	.009	.001	3	3
UCEC	ACC1 →	+0.286	+1.920	.010	.008	3	2
UCEC	Shc_pY317 →	-0.207	-2.222	<.001	<.001	3	2
UCEC	ASNS →	+0.463	+1.473	<.001	.006	3	2
UCEC	ATM →	-0.312	-2.102	.024	.016	3	2
UCEC	Caspase-8 →	-0.242	-3.295	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

eIF4E by REPS2 expression — UCEC

Explore this box plot interactively →