REPS1

Across TCGA pan-cancer cohorts, REPS1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated REPS1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher REPS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated REPS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

PDAC, UCEC, and CCRCC are the cancer types where REPS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.233	0.565	<.001	24	view →
UCEC	OS	Median	II,III,IV	1.000	0.609	.008	12	view →
CCRCC	OS	Tertile	II,III,IV	1.000	0.813	.017	11	view →
LSCC	OS	Quartile	All	1.000	0.850	.034	10	view →
HNSC	DFS	Tertile	All	0.992	0.894	.016	9	view →
LUAD	OS	Median	II,III,IV	0.429	1.000	.004	5	view →
GBM	DFS	Quartile	All	0.490	0.267	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

REPS1–PDAC (OS)

Open the PDAC breakdown →