REPS1

Across TCGA patient cohorts, REPS1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REPS1-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and JNK_pT183_Y185. Each is linked with REPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both REPS1-to-partner and partner-to-REPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by REPS1-low versus REPS1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REPS1→partner) and Y-score (partner→REPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EGFR_pY1068 →	-0.438	-2.991	.009	.036	3	2
UCEC	INPP4B →	-0.285	-3.807	.006	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.152	-1.362	.005	.034	3	2
UCEC	Notch1 →	+0.191	+1.778	<.001	.007	3	2
UCEC	PCNA →	+0.206	+1.459	.003	.012	3	2
UCEC	PDCD4 →	-0.502	-1.838	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

EGFR_pY1068 by REPS1 expression — COAD

Explore this box plot interactively →