REPS1

Across TCGA cell cohorts, REPS1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible REPS1-associated genes across cancer lineages are CFHR2, OR2A5, and KIR2DL3. Each is linked with REPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both REPS1-to-partner and partner-to-REPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by REPS1-low versus REPS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REPS1→partner) and Y-score (partner→REPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	2
SKIN	OR2A5 →	+0.103	+4.977	<.001	.007	3	1
SKIN	KIR2DL3 →	+0.006	+4.977	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	SPO11 →	+0.092	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR13C3 →	+0.018	+4.887	<.001	.009	3	1
BLOOD_Leukemia	GFRA4 →	+0.295	+4.409	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CFHR2 by REPS1 expression — LARGE_INTESTINE

Explore this box plot interactively →