REP15

Across TCGA patient cohorts, REP15 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REP15-associated genes across cancer lineages are Notch1, VHL, and Caspase-7-cleavedD198. Each is linked with REP15 in more than 1 cancer types. Because this analysis shows association rather than direction, both REP15-to-partner and partner-to-REP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by REP15-low versus REP15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REP15→partner) and Y-score (partner→REP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.192	+3.321	.009	.010	3	1
UCEC	VHL →	-1.076	-3.169	.002	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+1.185	+3.321	<.001	.010	3	1
UCEC	p62 Lck ligand →	+0.552	+3.321	.001	.010	2	1
UCEC	PCNA →	+0.311	+3.321	.006	.010	2	1
UCEC	PRDX1 →	+0.340	+3.000	.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by REP15 expression — UCEC

Explore this box plot interactively →