RENBP

Across TCGA patient cohorts, RENBP mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RENBP-associated genes across cancer lineages are Annexin-1, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with RENBP in more than 1 cancer types. Because this analysis shows association rather than direction, both RENBP-to-partner and partner-to-RENBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by RENBP-low versus RENBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RENBP→partner) and Y-score (partner→RENBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.534	+3.341	.009	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.687	+1.894	.003	.030	3	2
UCEC	EGFR_pY1068 →	-0.204	-2.000	.038	.010	3	1
UCEC	A-Raf_pS299 →	-0.100	-2.321	.033	.034	3	1
UCEC	Fibronectin →	-0.276	-3.449	.033	.005	3	1
UCEC	GSK-3_pS9 →	-0.374	-2.000	.018	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Annexin-1 by RENBP expression — UCEC

Explore this box plot interactively →