RENBP

Across TCGA cell cohorts, RENBP mutation is significantly associated with the mutation status of many other genes, with 801 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RENBP-associated genes across cancer lineages are SPHK2, SCO2, and KBTBD2. Each is linked with RENBP in more than 2 cancer types. Because this analysis shows association rather than direction, both RENBP-to-partner and partner-to-RENBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPHK2 grouped by RENBP-low versus RENBP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RENBP→partner) and Y-score (partner→RENBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPHK2 →	+2.894	+4.432	.005	.005	1	3
BLOOD_Leukemia	SCO2 →	+4.309	+4.560	.007	.007	1	3
UPPER_AERODIGESTIVE_TRACT	KBTBD2 →	+5.392	+5.392	.004	.004	1	3
BLOOD_Leukemia	FOXRED2 →	+3.479	+4.932	.002	.002	1	2
BLOOD_Leukemia	EIF3D →	+4.309	+4.560	.007	.007	1	2
LARGE_INTESTINE	CTSZ →	+4.523	+5.087	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 801 associations by consensus.

SPHK2 by RENBP expression — BLOOD_Leukemia

Explore this box plot interactively →