REN

Across TCGA patient cohorts, REN mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REN-associated genes across cancer lineages are ERK2, FOXO3a_pS318_S321, and Annexin-1. Each is linked with REN in more than 1 cancer types. Because this analysis shows association rather than direction, both REN-to-partner and partner-to-REN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by REN-low versus REN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REN→partner) and Y-score (partner→REN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.249	+3.169	.018	.020	3	1
UCEC	FOXO3a_pS318_S321 →	-0.159	-3.169	.020	.020	3	1
UCEC	Annexin-1 →	+0.838	+2.827	.003	.035	3	1
UCEC	STAT3_pY705 →	-0.527	-3.169	<.001	.020	3	1
UCEC	GATA6 →	-0.180	-3.162	.033	.019	2	1
UCEC	4E-BP1 →	+0.628	+3.169	<.001	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ERK2 by REN expression — UCEC

Explore this box plot interactively →