REN

Across TCGA cell cohorts, REN RNA expression is significantly associated with the go_rna of many other GO terms, with 979 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible REN-associated GO terms across cancer lineages are Extrinsic apoptotic signaling pathway in absence of ligand, Signal transduction in absence of ligand, and Positive regulation of high-density lipoprotein particle clearance. Each is linked with REN in more than 6 cancer types. Because this analysis shows association rather than direction, both REN-to-partner and partner-to-REN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Extrinsic apoptotic signaling pathway in absence of ligand grouped by REN-low versus REN-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (REN→partner) and Y-score (partner→REN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Extrinsic apoptotic signaling pathway in absence of ligand →	+0.123	+0.207	<.001	.001	3	7
LUNG_SCLC	Signal transduction in absence of ligand →	+0.124	+0.200	<.001	.001	3	6
OESOPHAGUS	Positive regulation of high-density lipoprotein particle clearance →	+1.166	+0.389	.002	<.001	3	6
OESOPHAGUS	Dermatan sulfate proteoglycan catabolic process →	+0.153	+0.281	.004	.006	3	6
LUNG_NSCLC_LUSC	Positive regulation of luteinizing hormone secretion →	+0.961	+0.314	.003	.001	3	6
LUNG_NSCLC_LUAD	Regulation of blood-brain barrier permeability →	+0.206	+0.247	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 979 associations by consensus.

Extrinsic apoptotic signaling pathway in absence of ligand by REN expression — LUNG_SCLC

Explore this box plot interactively →