REN

Across TCGA cell cohorts, REN mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible REN-associated genes across cancer lineages are ADIPOQ, FMO1, and PROKR1. Each is linked with REN in more than 1 cancer types. Because this analysis shows association rather than direction, both REN-to-partner and partner-to-REN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADIPOQ grouped by REN-low versus REN-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REN→partner) and Y-score (partner→REN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADIPOQ →	+0.029	+5.228	<.001	.005	3	1
LARGE_INTESTINE	FMO1 →	+0.138	+3.658	<.001	.005	3	1
LARGE_INTESTINE	PROKR1 →	+0.057	+3.725	<.001	.008	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1
LARGE_INTESTINE	VWC2L →	+0.009	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR2V2 →	+0.018	+3.510	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ADIPOQ by REN expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →