REM1

Across TCGA patient cohorts, REM1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REM1-associated genes across cancer lineages are VHL, A-Raf_pS299, and Gab2. Each is linked with REM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both REM1-to-partner and partner-to-REM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by REM1-low versus REM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REM1→partner) and Y-score (partner→REM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.750	-2.321	.027	.034	3	2
UCEC	A-Raf_pS299 →	-0.154	-3.000	.010	.036	3	1
UCEC	Gab2 →	+0.415	+2.321	.020	.035	3	1
UCEC	MEK1 →	+0.474	+2.321	.009	.035	3	1
UCEC	p21 →	+0.211	+2.321	.029	.035	3	1
UCEC	PEA-15 →	+0.214	+2.321	.023	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

VHL by REM1 expression — UCEC

Explore this box plot interactively →