RELT

Across TCGA patient cohorts, RELT mutation is significantly associated with the RNA expression of many other genes, with 1,489 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RELT-associated genes across cancer lineages are OR4C15, RNU6-13P, and SNORD116-3. Each is linked with RELT in more than 1 cancer types. Because this analysis shows association rather than direction, both RELT-to-partner and partner-to-RELT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4C15 grouped by RELT-low versus RELT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELT→partner) and Y-score (partner→RELT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR4C15 →	+0.036	+4.743	<.001	.005	3	2
UCEC	RNU6-13P →	+0.274	+2.384	.001	.002	3	2
UCEC	SNORD116-3 →	+0.229	+2.492	.003	.008	3	2
UCEC	MIR196A2 →	+0.143	+2.551	.005	.007	3	2
UCEC	MTATP6P29 →	+0.263	+2.755	<.001	.001	3	2
BLCA	IGKV2-10 →	+0.106	+5.018	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,489 associations by consensus.

OR4C15 by RELT expression — SKCM

Explore this box plot interactively →