RELT

Across TCGA cell cohorts, RELT mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible RELT-associated genes across cancer lineages are MBL2, CSHL1, and TP53TG3E. Each is linked with RELT in more than 1 cancer types. Because this analysis shows association rather than direction, both RELT-to-partner and partner-to-RELT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBL2 grouped by RELT-low versus RELT-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELT→partner) and Y-score (partner→RELT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MBL2 →	+0.007	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	CSHL1 →	+0.013	+4.539	.006	.007	3	1
BLOOD_Leukemia	TP53TG3E →	+0.029	+4.874	<.001	.002	3	1
OVARY	CABS1 →	+0.025	+3.990	.001	.003	3	1
OVARY	TPPP2 →	+0.087	+3.657	<.001	.009	3	1
OVARY	ACSM4 →	+0.015	+3.700	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MBL2 by RELT expression — BLOOD_Leukemia

Explore this box plot interactively →