Across TCGA pan-cancer cohorts, RELN mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RELN data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RELN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RELN expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where RELN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.942	0.640	.034	8	view →
LUAD	DFS	Median	III,IV	0.539	0.995	.018	5	view →
HNSC	OS	Tertile	II,III,IV	0.769	1.000	.014	5	view →
LSCC	DFS	Tertile	All	0.529	0.813	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: RELN tumor-vs-normal RNA expression · all RELN data types