Across TCGA patient cohorts, RELN protein abundance is significantly associated with the RNA expression of many other genes, with 2,404 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RELN-associated genes across cancer lineages are HPS4, ZNF346, and TLCD5. Each is linked with RELN in more than 1 cancer types. Because this analysis shows association rather than direction, both RELN-to-partner and partner-to-RELN results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELN→partner) and Y-score (partner→RELN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HPS4 →	-0.769	-0.542	.006	.002	3	2
UCEC	ZNF346 →	-0.673	-0.672	<.001	.003	3	2
HNSC	TLCD5 →	-0.936	-1.213	<.001	.004	3	2
UCEC	DEFB136 →	-0.806	-0.494	.003	.008	3	2
UCEC	TSPOAP1-AS1 →	-1.237	-0.551	<.001	.004	3	2
LSCC	COMMD4 →	-0.338	-0.566	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,404 associations by consensus.

Exploration

RELN survival (RNA) · tumor vs normal (RNA) · all RELN data types