Across TCGA patient cohorts, RELN mutation is significantly associated with the RNA expression of many other genes, with 8,997 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RELN-associated genes across cancer lineages are CDCA2, FAM136A, and GIT1. Each is linked with RELN in more than 6 cancer types. Because this analysis shows association rather than direction, both RELN-to-partner and partner-to-RELN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELN→partner) and Y-score (partner→RELN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA2 →	+0.631	+1.479	<.001	<.001	3	7
STAD	FAM136A →	+0.345	+2.251	.002	<.001	3	6
UCEC	GIT1 →	+0.292	+1.828	<.001	<.001	3	6
STAD	AUNIP →	+0.429	+3.857	.007	<.001	3	6
UCEC	RFC2 →	+0.379	+1.134	<.001	<.001	3	6
UCEC	RAD54L →	+0.490	+2.201	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,997 associations by consensus.

Exploration

RELN survival (RNA) · tumor vs normal (RNA) · all RELN data types