Across TCGA patient cohorts, RELN mutation is significantly associated with the total protein of many other genes, with 95 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RELN-associated genes across cancer lineages are Cyclin-B1, Cyclin-E2, and 4E-BP1. Each is linked with RELN in more than 4 cancer types. Because this analysis shows association rather than direction, both RELN-to-partner and partner-to-RELN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELN→partner) and Y-score (partner→RELN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Cyclin-B1 →	+0.548	+3.000	.021	.037	3	5
LUAD	Cyclin-E2 →	+0.101	+1.264	.004	.022	3	4
UCEC	4E-BP1 →	+0.243	+1.938	<.001	.001	3	4
BRCA	INPP4B →	-0.566	-3.000	.016	.037	3	4
BRCA	PCNA →	+0.163	+2.336	.048	.020	3	4
UCEC	STAT3_pY705 →	-0.298	-1.352	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

Exploration

RELN survival (RNA) · tumor vs normal (RNA) · all RELN data types