Across TCGA cell cohorts, RELN mutation is significantly associated with the RNA expression of many other genes, with 1,142 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RELN-associated genes across cancer lineages are RWDD2A, MYL9, and OR8B12. Each is linked with RELN in more than 2 cancer types. Because this analysis shows association rather than direction, both RELN-to-partner and partner-to-RELN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELN→partner) and Y-score (partner→RELN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RWDD2A →	+0.448	+2.115	<.001	.004	3	3
LUNG_NSCLC_LUAD	MYL9 →	-1.544	-3.206	.008	.005	3	3
LUNG_NSCLC_LUAD	OR8B12 →	+0.023	+1.957	<.001	<.001	3	3
BLOOD_Leukemia	PEMT →	+0.557	+3.562	.001	.001	3	3
BLOOD_Leukemia	TTC5 →	+0.450	+2.222	.004	.003	3	3
BLOOD_Leukemia	DHX33 →	+0.483	+3.459	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,142 associations by consensus.

Exploration

RELN survival (RNA) · tumor vs normal (RNA) · all RELN data types