RELL2

Across TCGA patient cohorts, RELL2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RELL2-associated genes across cancer lineages are EGFR_pY1068, GATA6, and PCNA. Each is linked with RELL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RELL2-to-partner and partner-to-RELL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RELL2-low versus RELL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELL2→partner) and Y-score (partner→RELL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.286	-3.169	.018	.019	3	1
UCEC	GATA6 →	-0.153	-3.452	.048	.005	3	1
UCEC	PCNA →	+0.221	+3.169	.034	.019	3	1
UCEC	Tuberin →	+0.306	+2.999	.018	.035	3	1
UCEC	ASNS →	+0.626	+2.459	<.001	.020	3	1
UCEC	STAT3_pY705 →	-0.460	-3.449	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by RELL2 expression — UCEC

Explore this box plot interactively →