RELL1

Across TCGA pan-cancer cohorts, RELL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RELL1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RELL1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RELL1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where RELL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	0.854	0.385	<.001	28	view →
LSCC	OS	Median	III,IV	0.938	0.423	.002	19	view →
PDAC	DFS	Quartile	III,IV	0.272	0.975	.006	13	view →
HNSC	OS	Median	II,III,IV	0.631	0.820	.010	7	view →
GBM	OS	Quartile	All	0.318	0.597	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RELL1–CCRCC (OS)

Open the CCRCC breakdown →