RELL1

Across TCGA patient cohorts, RELL1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RELL1-associated genes across cancer lineages are Notch1, p62 Lck ligand, and Tuberin. Each is linked with RELL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RELL1-to-partner and partner-to-RELL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by RELL1-low versus RELL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELL1→partner) and Y-score (partner→RELL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.189	+3.000	.020	.037	3	1
UCEC	p62 Lck ligand →	+0.439	+2.817	.019	.036	3	1
UCEC	Tuberin →	+0.406	+3.000	.009	.037	3	1
UCEC	VHL →	-1.132	-3.000	.003	.036	3	1
UCEC	XBP1 →	-0.261	-3.000	.001	.037	3	1
UCEC	IGFBP2 →	-0.913	-3.000	.015	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by RELL1 expression — UCEC

Explore this box plot interactively →